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1985年至1988年6月作者用Ganciclovir治疗了9例肾移植病人合并严重的巨细胞病毒(CMV)感染,其中男性5例,女性4例,年龄16～65岁。5例为致命的CMV性肺炎,4例有严重的全身性病毒血症症状(即长期消耗性发热和虚弱)。8例经支气管肺泡灌洗液或血液的直接免疫萤光检查或培养证实为CMV。8例CMV血清学阴性的肾移植受者移植术后血清转阳,1例CMV阳性的肾移植受者移植术后滴度显著升高(>4倍)。Ganciclovir的剂量为5 mg/kg,每日两次静滴,每次不短于1小时,共14天。治疗后7例反应良好,临床症状很快改善,病人存活,移植肾功能良好。2例
Between 1985 and June 1988, Ganciclovir treated nine patients with renal allograft with severe cytomegalovirus (CMV) infection, including 5 males and 4 females, aged 16-65 years. Five were deadly CMV pneumonia and four had severe symptoms of systemic viraemia (ie, long-term fever and weakness). Eight cases of bronchoalveolar lavage fluid or blood by direct immunofluorescence examination or culture confirmed as CMV. Eight patients with CMV-seronegative renal transplant recipients had positive serum levels of serum transfusion, and one case of CMV-positive kidney transplant recipients had a significantly higher titer (> 4-fold) after transplantation. Ganciclovir at a dose of 5 mg / kg, intravenous infusion twice a day, not less than 1 hour each for a total of 14 days. After treatment, 7 patients responded well, the clinical symptoms improved rapidly, the patients survived, and the function of kidney graft was good. 2 cases