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目的探讨18F-氟代脱氧葡萄糖(18F-FDG)PET/CT评价乳腺癌术后复发、转移及预后的应用价值。方法回顾性分析43例乳腺癌术后患者相关临床及影像检查资料,比较18 F-FDG PET/CT检查标准摄取最大值(SUVmax)变化,采用Spearman相关性分析病灶SUVmax与预后的关系。结果 18F-FDG PET/CT对术后乳腺癌复发或转移灶检出的灵敏度、特异度和准确度分别为96.5%、92.9%和95.3%。术后证实有乳腺癌复发或转移灶者28例。治疗后复查PET/CT结果:9例有效稳定,SUVmax较治疗前下降(4.1±2.8vs.8.3±4.9)(P<0.05);7例病情恶化,SUVmax较治疗前上升(7.9±3.8vs.4.3±2.3)(P<0.05);带病生存18例的SUVmax低于10例进展死亡患者(5.4±2.6vs.9.4±3.2)(P<0.01)。病灶SUVmax与预后呈负相关(r=-0.55,P<0.05)。结论 18F-FDG PET/CT评估乳腺癌术后患者复发、转移、预后有重要临床价值。
Objective To investigate the value of 18F-fluorodeoxyglucose (18F-FDG) PET / CT in the evaluation of postoperative recurrence, metastasis and prognosis of breast cancer. Methods The clinical and imaging data of 43 postoperative patients with breast cancer were retrospectively analyzed. The maximum standard ingestion (SUVmax) of 18 F-FDG PET / CT was compared. Spearman’s correlation was used to analyze the relationship between the SUVmax and prognosis. Results The sensitivity, specificity and accuracy of 18F-FDG PET / CT for detecting recurrence or metastasis of breast cancer were 96.5%, 92.9% and 95.3% respectively. Postoperative confirmed breast cancer recurrence or metastasis in 28 cases. The results of PET / CT examination after treatment were as follows: 9 cases were effective and stable, SUVmax decreased (4.1 ± 2.8 vs.8.3 ± 4.9) before treatment (P <0.05); 7 cases worsened and SUVmax increased (7.9 ± 3.8 vs. 4.3 ± 2.3) (P <0.05). The SUVmax of 18 patients with disease-free survival was lower than 10 patients with progression-free death (5.4 ± 2.6 vs 9.4 ± 3.2) (P <0.01). SUVmax was negatively correlated with prognosis (r = -0.55, P <0.05). Conclusion 18F-FDG PET / CT evaluation of breast cancer patients with recurrence, metastasis, prognosis of important clinical value.