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近年来,国外倾向用大剂量阿糖胞苷或联合其他药物强烈的方案诱导治疗成人急性淋巴细胞白血病(AALL),但毒副作用大。国内用VCDP(长春新(石全)、环磷酰胺、柔红霉素、泼尼松)方案治疗AALL,疗效亦欠满意,缓解率在66--82.6%。用VAD(长春新(石全)、阿霉素、地塞米松)方案治疗慢性粒细胞白血病急淋变,多发性骨髓瘤有较好疗效,副作用不大,未见用于AALL。本文报道用VAD方案治疗AALL10例的结果。
In recent years, foreign countries tend to use high doses of cytarabine or other drugs in conjunction with strong programs to induce the treatment of adult acute lymphoblastic leukemia (AALL), but the toxic side effects. Domestic use of VCDP (Changchun new (Shiquan), cyclophosphamide, daunorubicin, prednisone) for the treatment of AALL, the effect is not satisfied with the response rate was 66--82.6%. With VAD (Changchun new (Shiquan), doxorubicin, dexamethasone) treatment of acute lymphocytic leukemia, multiple myeloma has a good effect, little side effects, has not been used for AALL. This article reports the results of treatment of AALL10 cases with VAD regimen.