恶性肿瘤是一大类严重威胁人类生命和健康的疾病。化疗作为全身性的治疗手段,在恶性肿瘤的综合治疗中具有不可替代的地位,但目前化疗的疗效仍不理想。由于肿瘤本身存在着异质性,即便同一组织学类型,分化程度相同的肿瘤对同一药物的敏感性也不同。而且化疗药物一般都具有较强的 Malignancies are a large group of diseases that seriously threaten human life and health. As a systemic treatment, chemotherapy has an irreplaceable role in the comprehensive treatment of malignant tumors, but the effect of chemotherapy is still unsatisfactory. Because of the inherent heterogeneity of tumors, tumors of the same degree of differentiation have different sensitivities to the same drug even in the same histological type. And chemotherapy drugs are generally strong