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细胞色素P4502A13(CYP2A13)是近年来新发现的具有代谢活化作用的细胞色素P450酶。该酶主要存在于呼吸系统,主要参与多种外源性药物及毒物的代谢。近年来研究发现,CYP2A13具有基因多态现象,这使该酶在不同人群的酶活性大小不同。而这可能与肿瘤发生的易感性大小有关。本文将着重对近年来该酶的多态性研究予以简要阐述。
Cytochrome P4502A13 (CYP2A13) is a recently discovered cytochrome P450 enzyme with metabolic activation. The enzyme mainly in the respiratory system, mainly involved in a variety of exogenous drugs and toxic metabolism. In recent years, studies have found that CYP2A13 gene polymorphism, which makes the enzyme in different populations of different sizes of enzymes. And this may be related to the size of the tumor susceptibility. This article will focus on the enzyme in recent years, the study of polymorphisms to be briefly described.