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目的探讨液基细胞学检测(TCT)在宫颈癌筛查中的应用效果。方法选取2015年6月至2016年12月间眉山市妇幼保健院收治的760例宫颈筛查患者,所有患者均行TCT检测,对于TCT阳性的患者行阴道镜检测,以病理诊断为金标准,观察分析TCT检测的准确度和特异度。结果760例患者中液基细胞学异常者159例(20.9%),其中不典型鳞状细胞(ASCUS)75例(9.9%),高度鳞状上皮内病变(HSIL)43例(5.7%),低度鳞状上皮内病变(LSIL)41例(5.4%)。159例患者阴道镜下宫颈活检术发现,宫颈上皮内瘤变(CIN)I患者73例(45.9%)。在75例ASCUS患者中,阴道镜检查CIN I 41例,CIN II 18例,TCT诊断符合率为78.7%;43例HSIL患者中,阴道镜检查CIN I14例,CIN II 18例,CIN III 6例,3例宫颈癌,符合率为95.3%;41例LSIL患者中,阴道镜检查CIN I18例,CIN II 13例,CIN III 3例,符合率为82.9%。结论 TCT检查在宫颈癌筛查中准确度较高,可为临床诊断提供一定的依据。
Objective To investigate the application effect of liquid-based cytology (TCT) in cervical cancer screening. Methods A total of 760 cervical screening patients admitted to Meishan MCH from June 2015 to December 2016 were enrolled in this study. All patients underwent TCT. Colposcopy was performed on patients with positive TCT. Pathological diagnosis was the gold standard, Observe and analyze the accuracy and specificity of TCT. Results Among the 760 patients, 159 (20.9%) had abnormal liquid-based cytology, including 75 (9.9%) with atypical squamous cell carcinoma (ASCUS) and 43 with high-grade squamous intraepithelial lesion (HSIL) Low grade squamous intraepithelial lesion (LSIL) in 41 cases (5.4%). A total of 159 patients (45.9%) with cervical intraepithelial neoplasia (CIN) I were examined by colposcopic biopsy. Among 75 ASCUS patients, colposcopy CIN I 41 cases, CIN II 18 cases, TCT diagnosis coincidence rate was 78.7%; 43 cases of HSIL patients colposcopy CIN I 14 cases, CIN II 18 cases, CIN III 6 cases , 3 cases of cervical cancer, the coincidence rate was 95.3%. Among 41 LSIL patients, CIN I was detected by colposcopy in 13 cases, CIN II in 13 cases and CIN III in 3 cases, the coincidence rate was 82.9%. Conclusion The accuracy of TCT screening in cervical cancer screening is high, which can provide some evidences for clinical diagnosis.