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目的观察中西医结合治疗小儿脓毒症的临床疗效及对肾功能的影响。方法按照随机数字表法将本组纳入的106例患儿随机分为治疗组(n=53)和对照组(n=53)。治疗组采用中西医结合治疗,对照组单用西药治疗。治疗7 d后,评价2组患儿的疗效、治疗前后急性生理学与慢性健康状态II(APACHE II)评分变化、治疗前后白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平以及治疗前后肾功能变化。结果治疗组总有效率(96.23%)显著高于对照组(81.13%)(P<0.05),治疗组患儿治疗后APACHE II评分、IL-6和TNF-α水平显著低于对照组,差异均有统计意义(P<0.05);2组患儿治疗前后尿素氮(BUN)和血清肌酐(Scr)比较,差异均无统计意义(P>0.05)。结论中西医结合治疗小儿脓毒症临床疗效显著,可降低患儿炎症反应,并对肾功能无明显影响,具有重要的临床研究意义。
Objective To observe the clinical efficacy and the effect on kidney function of pediatric sepsis treated with integrated traditional Chinese and western medicine. Methods According to the random number table method, 106 children enrolled in this study were randomly divided into treatment group (n = 53) and control group (n = 53). Treatment group with Integrative Medicine, control group with Western medicine alone. After 7 days of treatment, the curative effect of the two groups of children was evaluated. The changes of acute physiology and chronic health status II (APACHE II) before and after treatment were observed. The levels of IL-6 and TNF- α) levels and changes in renal function before and after treatment. Results The total effective rate (96.23%) in the treatment group was significantly higher than that in the control group (81.13%) (P <0.05). The APACHE II score, IL-6 and TNF-α levels in the treatment group were significantly lower than those in the control group (P <0.05). There was no significant difference in BUN and Scr between the two groups before and after treatment (P> 0.05). Conclusion Integrative treatment of pediatric sepsis clinical curative effect is significant, can reduce the inflammatory response in children with no significant effect on renal function, has important clinical significance.