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体内滴注ACTH后,血浆醛固酮(P-Aldo)升高。血浆肾素活性(PRA),血管紧张素Ⅱ(AGⅡ)血浆皮质醇(PTF)亦相应增加,为了评价ACTH对PRA刺激作用,滴注前服用消炎痛及心得安,以进一步阐明其ACTH的作用机制。 每天用10单位ACTH(1—24)输注正常男性,所有受试者每天膳食含钠10—20mM和钾70mM平均钠摄取量为135mM,输注前一天为对照试验,输注日从7Am开始至次日6Pm共36小时。实验分
In vivo infusion of ACTH, plasma aldosterone (P-Aldo) increased. In order to evaluate the stimulating effects of ACTH on PRA, the activity of plasma renin (PRA) and plasma cortisol (AGF) of angiotensin Ⅱ (AGⅡ) were also increased. Indomethacin and propranolol were administered before instillation to further elucidate the role of ACTH mechanism. Normal males were infused daily with 10 units of ACTH (1-24), and all subjects had daily dietary sodium 10-20 mM and potassium 70 mM with an average sodium intake of 135 mM. The day before the infusion was the control and the day of infusion started at 7Am 6Pm the next day a total of 36 hours. Experimental points