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目的:研究海水浸泡对失血性休克大鼠血流动力学的影响,并探讨其改变机理.方法:采用雄性WISTAR大鼠,分为三组:正常对照组(N＝10);平原休克组(N＝10)海水浸泡夫血性休克组(N＝10).测定血流动力学指标,血浆磷脂酶A2(PLA2)活性,心肌和心肌线粒体钙含量,心肌线粒体(CA2+MG(2+)－ATPASE活性变化,血浆和心肌MDA的变化.结果:海水浸泡失血性休克动物血流动力学明显低于平原失血性休克组.海水浸泡失血性休克组动物心肌钙超载显著重于平原休克组,心肌和心肌线粒体钙含量均高于平原休克组,心肌线粒体CA(2+)－MG(2+)-ATPASE活性显著低于平原休克组.结论:海水浸泡失血性休克动物钙超载,脂质过氧化及PLA2升高可能是血流动力学下降的原因.“,”Objective: To investigate the changes and its mechanism of hemodynamics for hemorrhagic shock rats immersed in seawater.Methods: Thirty male rats were divided into three groups randomly: control. group (n=10); hemorrhagic shock group on land (n=10)and hemorrhagic shock group immersed in seawater (n=10). The hemodynamic parameters and the plasma PLA2 activity, thecalcium MDA contents of myocardium its mitochondria, and Ca2+-Mg2+-ATPase of myocardium mitochondria was measuredrespectively. The Results were performed T-test with Windows Excell5.0. Results: Hemodynamic indexes in seawater immersinghemorrhagic shock group were significantly lower than those in the control group and the hemorrhagic shock group on land(P<0.05). Plasma PLA, activity, MDA Calcium contents of myocardium and mitochondria in seawater immersing hemorrhagicshock group were significantly higher than those in the control group and the plain hemorrhagic shock group respectively. But H+ATPase and Ca2+-Mg2+-ATPase in seawater immersing hemorrhagic shock group were significantly lower than those in plainhemorrhagic shock group. Conclusions: Overloading calcium, lipoperxides and elevated PLA, occurred in seawater immersinghemorrhagic shock animals may be the reasons for hemodynamic reduction.