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婴儿痉挛症是以点头发作和智力发育障碍为主的特殊类型癫病。Vizioli(1962)在468例小儿癫痫分析中婴儿痉挛症占第二位,如除去发热惊厥则占第一位。Friedlander(1963)在622例婴儿痉挛症的预后分析中发现23例死亡,142例必须送入收容所,其余457例中只有11例智力发育正常。德国学派称之谓恶性点头痉挛。近20年来关于本病发病机理的研究有了很大的进展,本文仅就病因、病理、致病机制以及智力障碍等有关研究成果综述于下。
Infantile spasms is a special type of epilepsy mainly due to hair loss and mental retardation. Vizioli (1962) accounted for the second most common cause of infantile spasms in 468 cases of pediatric epilepsy, with febrile seizures being the first. In a prospective analysis of 622 infantile spasms, Friedlander (1963) found 23 deaths, 142 had to be sent to a shelter, and only 11 of 457 others had normal mental development. German school called malignant nodding spasm. The past 20 years on the pathogenesis of this disease has made great progress in this article only etiology, pathology, pathogenesis and mental retardation and other related research results summarized in the next.