内皮素(ET)具有很强的血管收缩作用,可能参与了肾循环的动态变化,并影响肾功能。ET与急性肾功能不全的原因密切相关,但这一问题尚未进行详细的研究。作者用犬肾动脉内持续注射不同剂量的ET来了解ET对肾脏的直接作用,同时探讨ET对作用于肾脏的药物疗效的影响。作者用戍巴比妥麻醉犬,人工呼吸,暴露左 Endothelin (ET) has a strong vasoconstriction, may be involved in the dynamic changes of renal circulation, and affect renal function. ET and acute renal insufficiency are closely related to the reasons, but this issue has not been studied in detail. The authors used canine renal artery continuous injection of different doses of ET to understand the direct effect of ET on the kidney, and explore the effect of ET on the efficacy of the drug on the kidneys. The author anesthetized dogs with pentobarbital, artificial respiration, left exposed