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进一步研究了卤代芳酰异硫氰与异烟酰肼反应,制得一系列1-异烟酰基-4-卤代芳酰基氨基硫脲,并观察了这些新药物的抗结核菌性能,其中以1-异烟酰基-4-对碘苯甲酰基-氨基硫脲抗结核菌作用最强。
A series of 1-isonicotinoyl-4-haloaromatic thiosemicarbazones were also prepared by the reaction of isocyclohexanoyl isothiocyanate with isonicotinoylhydrazide. The anti-tuberculotic properties of these new drugs were observed, among them To 1-isonicotinoyl-4-p-iodobenzoyl-thiosemicarbazide most effective.