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为了探索乙型肝炎病毒（HBV）E抗原抗体系统的变化与慢性肝病的肝损程度及肝癌发生是否有关系，本文采用Elisa法对243例不同慢性肝病患者进行乙型肝炎病毒E抗原抗体系统检测，同时采用PCR法进行HBVDNA的检测．其结果提示：180例抗-HBe阳性的血清检出101例HBVDNA阳性，其阳性率为56％（101／180）；同时发现抗-HBe的检出率在肝细胞癌（HCC）组、肝炎后肝硬化（LC）组、慢性肝炎（中、重度CH）组中分别为83％（57／69）、78％（54／69）、75％（54／72），明显高于慢性肝炎（轻度CH）组，其检出率为45％（15／33）．结果说明：HBeAg阴转和／或抗-HBe阳转并不意味着病毒复制水平明显降低，临床不具传染性；而且抗-HBe的出现与加重肝细胞损害程度或肝细胞癌变可能有一定的关系，不能忽视对病程的随访与监测。
In order to explore whether the change of antibody system of hepatitis B virus (E) antigen is related to the degree of liver damage and the occurrence of HCC, Elisa method was used to detect the antibody of Hepatitis B virus E antigen in 243 patients with chronic liver disease , At the same time using PCR method for detection of HBVDNA. The results suggest that: out of 180 cases of anti-HBe positive serum detected 101 cases of HBVDNA positive, the positive rate was 56% (101/180); also found anti-HBe detection rate in hepatocellular carcinoma (HCC) group, hepatitis 83% (57/69), 78% (54/69) and 75% (54/72) in the group of chronic hepatitis (cirrhosis), chronic liver disease (LC) and chronic hepatitis Mild CH) group, the detection rate was 45% (15/33). The results show that: HBeAg negative and / or anti-HBe positive does not mean that the level of viral replication was significantly reduced, the clinical non-contagious; and the emergence of anti-HBe and aggravate the degree of hepatocellular damage or hepatocellular carcinoma may have a certain relationship , Can not ignore the follow-up and monitoring of the course of the disease.