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高血压左室重构是对慢性动脉压力超负荷的一种代偿性反应,压力负荷持续性增高将导致心肌收缩力下降。左室重构包括:①病理性心肌细胞肥大伴胚胎性基因再表达;②心肌细胞的凋亡与坏死;③细胞外基质过度沉积或降解增加[1]。
Hypertension Left ventricular remodeling is a compensatory response to chronic arterial pressure overload. Continued increase in pressure load will result in decreased myocardial contractility. Left ventricular remodeling includes: pathological cardiomyocyte hypertrophy with embryonic gene re-expression; cardiomyocyte apoptosis and necrosis; extracellular matrix over-deposition or increased degradation [1].