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目的 评价 1 53钐 -乙二胺四亚甲基膦酸盐 (1 53Sm- EDTMP)与 99m Tc亚甲基二膦酸盐 (商品名云克 )联合应用治疗多发性骨转移癌的疗效。方法 各种骨转移癌 132例 ,随机分组治疗 ,第 1组 4 2例患者仅静脉注射 1 53Sm- EDTMP,1.0× 10 7Bq/ kg,第 2组 5 0例患者 1 53Sm- EDTMP联合 99m Tc亚甲基二膦酸盐治疗 ,1 53Sm- EDTMP用量不变 ,并与静脉注射 1 53Sm- EDTMP后的第 5天开始用 99m Tc亚甲基二膦酸盐连续 5 d。第 3组 4 0例患者静脉滴注博宁 ,10 d1个疗程。结果 第 1组镇痛有效率为 6 1% ,疼痛缓解持续时间平均 4周。第 2组联合用药组镇痛有效率达 80 % ,疼痛缓解持续时间平均 8周。第 3组镇痛有效率 4 2 % ,疼痛缓解持续时间平均 2周。 3组疗效有显著统计学意义 (P<0 .0 5 )。结论 不论 1 53Sm - EDTMP单独使用还是与 99m Tc亚甲基二膦酸盐联合用药都是治疗多发骨转移的有效止痛方法 ,相比之下 ,联合用药可明显提高镇痛效率。
Objective To evaluate the efficacy of samarium-ethylenediaminetetramethylene phosphonate (153Sm-EDTMP) combined with 99m Tc methylene diphosphonate (trade name: Yunke) in the treatment of multiple bone metastases. Methods Thirty-two cases of all kinds of bone metastases were randomly divided into treatment group (n = 42), group B (n = 52), intravenous injection of 53Sm-EDTMP Methyl diphosphonate treatment, the amount of 153Sm-EDTMP unchanged, and with intravenous injection of 53Sm-EDTMP 5 days after starting with 99m Tc methylene diphosphonate for 5 d. The third group of 40 patients with intravenous Boning, 10 d1 a course of treatment. Results The first group analgesic effective rate was 61%, pain relief duration averaged 4 weeks. Group 2 combined with analgesic effective rate of 80%, pain relief duration of an average of 8 weeks. Group 3 analgesia effective 42%, pain relief duration of an average of 2 weeks. The efficacy of the three groups was statistically significant (P <0.05). Conclusions Either alone or in combination with 99m Tc methylene diphosphonate is an effective analgesia for the treatment of multiple bone metastases, in contrast to the combination of 1 53Sm - EDTMP alone and analgesia.