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目的研究大鼠大脑中动脉（ＭＣＡ）短暂闭塞后血脑屏障（ＢＢＢ）通透性与脑毛细血管内皮细胞（ＢＣＥＣｓ）凋亡。方法大鼠ＭＣＡ经腔内导入单线闭塞不同时间后再灌流２４ｈ，血管源性脑水肿（ＶＢＥ）的程度用分光光度法测定Ｅｖａｎｓ蓝（ＥＢ）渗出量评价，凋亡细胞用原位末端标记法观察。结果ＥＢ外渗量、凋亡的ＢＣＥＣｓ数显著高于对侧，随缺血时间的延长而增加，ＥＢ外渗量与凋亡的ＢＣＥＣｓ数显著相关。结论ＢＣＥＣｓ凋亡可能参与了ＶＢＥ的形成机制
Objective To study the permeability of the blood-brain barrier (BBB) and the apoptosis of brain capillary endothelial cells (BCECs) after transient occlusion of the middle cerebral artery (MCA) in rats. Methods Rat MCA was subjected to single-line occlusion at different time points and then perfused for 24 hours. The degree of vasculogenic brain edema (VBE) was assessed by the spectrophotometric method for Evans blue (EB) exudation. Law observation. Results The amount of EB extravasation and the number of apoptotic BCECs were significantly higher than those on the opposite side, and increased with the prolongation of ischemic time. The amount of EB extravasation was significantly correlated with the number of apoptotic BCECs. Conclusion The apoptosis of BCECs may be involved in the formation of VBE