论文部分内容阅读
乙酰肝素酶(heparanase,HPA)是目前发现的哺乳动物细胞中唯一能切割细胞外基质中硫酸肝素蛋白多糖侧链的内源性糖苷酶。因其可促进肿瘤细胞的浸润和转移,还可以促进肿瘤细胞生长和微血管形成,而被视为是抗肿瘤、抗炎症的理想靶点。研究表明HPA可以降解肾小球基底膜硫酸乙酰肝素多糖侧链,造成肾小球基底膜选择性滤过蛋白质功能下降,与糖尿病肾病(diabetic nephropathy,DN)蛋白尿的产生密切相关。HPA活性的高低对糖尿病肾病的研究有着重要的意义。现将HPA与DN之间的研究进展作一综述。
Heparanase (HPA) is the only endogenous glycosidase found in mammalian cells to cut heparin sulfate proteoglycan side chains in the extracellular matrix. Because it can promote tumor cell infiltration and metastasis, but also can promote tumor cell growth and microvascular formation, and is considered to be anti-tumor, anti-inflammatory ideal target. Studies have shown that HPA can degrade the side chain of glomerular basement membrane heparan sulfate proteoglycan, resulting in decreased glomerular basement membrane selective filtration protein function, and diabetic nephropathy (DN) proteinuria are closely related. The level of HPA activity is of great significance for the study of diabetic nephropathy. Now the research progress between HPA and DN is reviewed.