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复方磺胺甲基异恶唑(以下简称TMP-SMZ)是一种强有力的抗微生物药物,治疗各种感染均有效。其抗微生物的活性是连续阻断叶酸的合成。据报告,TMP-SMZ对血液学的影响主要和巨成红细胞的转变有关,此可能由于TMP对二氢叶酸还原酶的作用所致。但是,在巨成红细胞没有改变时,血小板减少症状或和粒细胞减少是否也是由于TMP或磺胺药成分引起,还不清楚。 2例输注血小板的病人,在TMP-SMZ治疗期间,输注的血小板存活减少[输注正常供血者血小板(平均输入150×10~9血小板)后一小时,可望增加循环中血小板数20～30×
Compound sulfamethoxazole (hereinafter referred to as TMP-SMZ) is a potent antimicrobial drug, effective in treating various infections. Its antimicrobial activity is the continuous block of folic acid synthesis. It has been reported that the effect of TMP-SMZ on hematology is mainly related to the transition of giant erythroid cells, possibly due to the effect of TMP on dihydrofolate reductase. However, it remains unclear whether thrombocytopenia or agranulocytosis is caused by TMP or sulfa drug components even when giant red blood cells are not changed. Two patients with platelet transfusions experienced reduced platelet transfusions during TMP-SMZ treatment [an increase of circulating platelets by one hour after infusion of normal donor blood platelets (150 x 10-9 platelets on average) ~ 30 ×