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目的：比较表皮生长因子受体（ＥＧＦＲ） 在肝细胞癌及胆管细胞癌中表达的差异。方法：采用免疫组化及原位杂交方法检测９２ 例肝细胞癌及５０ 例胆管细胞癌组织中ＥＧＦＲ蛋白及ｍ ＲＮＡ的表达。结果：９２ 例肝细胞癌标本中，４２ 例ＥＧＦＲ 蛋白或ｍＲＮＡ阳性，占４５－７％ 。５０ 例胆管细胞癌中，３６ 例ＥＧＦＲ蛋白或ｍＲＮＡ 阳性，占７２－０ ％ 。结论：与肝细胞癌相比，胆管细胞癌的发生、发展与ＥＧＦＲ 表达增高的关系更加密切。
Objective: To compare the expression of epidermal growth factor receptor (EGFR) in hepatocellular carcinoma and cholangiocarcinoma. Methods: Immunohistochemistry and in situ hybridization were used to detect the expression of EGFR protein and m RNA in 92 cases of hepatocellular carcinoma and 50 cases of cholangiocarcinoma. RESULTS: Among 92 cases of hepatocellular carcinoma specimens, 42 cases were positive for EGFR protein or mRNA, accounting for 45-7%. In 50 cases of cholangiocarcinoma, 36 cases of EGFR protein or mRNA were positive, accounting for 72 to 0%. Conclusion: Compared with hepatocellular carcinoma, the occurrence and development of cholangiocarcinoma are more closely related to the increased expression of EGFR.