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目的探讨两药联合应用治疗重度外阴阴道假丝酵母菌病(SVVC)的疗效及对阴道乳酸杆菌的影响。方法将2009-01-2010-12来河南省传染病医院就诊的SVVC患者分为观察组和对照组A、B,用不同方法治疗,观察疗效。结果观察组痊愈率95%,对照组A、B痊愈率80%、75%,两组比较差异有统计学意义(P<0.001);用药后7～14d阴道乳酸杆菌与用药前相比,差异无统计学意义(P>0.05)。结论硝酸咪康唑栓、伊曲康唑联合应用治疗SVVC效果显著。
Objective To investigate the curative effect of combined treatment of two drugs on severe vulvovaginal candidiasis (SVVC) and its influence on Lactobacillus. Methods The SVVC patients who came to Henan Infectious Disease Hospital from January 2009 to October 2010 were divided into two groups: observation group and control group. A and B were treated with different methods and the curative effect was observed. Results The cure rate of the observation group was 95%, the cure rate of the control group A and B was 80% and 75%, respectively. There was significant difference between the two groups (P <0.001) No statistical significance (P> 0.05). Conclusions The combination of miconazole nitrate suppository and itraconazole in treating SVVC has remarkable effect.