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比较了不同品系青老年鼠间ＮＫ细胞活性差异，以及细胞因子、ｒ—干扰素和白细胞介素—Ⅱ对青老年鼠ＮＫ细胞的激活作用。讨论了衰老与肿瘤发生的免疫学因素。结果表明，在青年Ｃ５７ＢＬ／６、Ｃ３Ｈ、Ｓｗｉｓｓ、ＤＢＡ／２及昆明鼠的ＮＫ细胞水平无明显差异，而在老年鼠差异非常显著，特别是Ｃ３Ｈ和Ｃ５７ＢＬ／６老年鼠在１年龄时基本丧失ＮＫ细胞活性。病毒感染老年鼠未见象青年鼠那样的ＮＫ激活现象，而老年鼠的ＮＫ细胞对细胞因子应答正常，提示老年鼠的免疫调节细胞（ＴＨ细胞）功能低下。
The differences of NK cell activity among different age groups were compared, and the effects of cytokines, r-interferon and interleukin-Ⅱ on NK cells in aged mice were compared. Discusses the immunological factors of aging and tumorigenesis. The results showed that there was no significant difference in the level of NK cells in young C57BL / 6, C3H, Swiss, DBA / 2 and Kunming mice, but significant difference in aged mice, especially in C3H and C57BL / 6 old mice NK cell activity. The virus-infected old mice showed no signs of NK-like activation in young mice, while NK cells in normal mice responded normally to cytokines, suggesting the hypofunction of immunoregulatory cells (TH cells) in aged mice.