论文部分内容阅读
为了解河南省原发性肝癌（PHC）发生中HBV、HCV的相互作用，我们应用ELISA法和PCR法对PHC患者及其1：1对照进行了HBV标志物（HBVM）和HCV标志物（HCVM）检测。结果：PHC患者HBVM阳性率为81．25％，对照组HBVM阳性率为9．60％，P＜0.01，OR=70（25．36，193．23）；PHC患者HCVM阳性率为19．79%，对照组HCVM阳性率为8.33％，P＜0.05，OR＝2．57（1．11，5．95）；PHC患者HBVM、HCVM双重阳性率为18．75％，对照组双重阳性率为1.04％，将HBVM和（或）HCVM阳性看成不同的暴露等级与HBVM和HCVM均阴性组进行比较，得到HBV和HCV双重感染时的OR值为83.65，明显高于两者分别感染的OR值（34．85和1．58）之积。结果提示：HBV、HCV在PHC的发生中有显著的病因协同作用。
To understand the interaction between HBV and HCV in the development of primary liver cancer (PHC) in Henan Province, we used ELISA and PCR to perform HBV markers (HBVM) and HCV markers (HCVM) on PHC patients and their 1:1 controls. ) Detection. Results: The positive rate of HBVM was 81.25% in PHC patients, 9.60% in control group, P<0.01, OR=70(25.36,193.23); the positive rate of HCVM in PHC patients was 19.79. %, The positive rate of HCVM in the control group was 8.33%, P<0.05, OR=2.57 (1.11, 5.95); the positive rate of HBVM and HCVM in PHC patients was 18.75%; the double positive rate in the control group 1.04%, HBVM and (or) HCVM positive as a different exposure level and HBVM and HCVM negative group were compared to obtain the HBV and HCV dual infection when the OR was 83.65, significantly higher than the OR of the two infections respectively The product of (34.85 and 1.58). The results suggest that HBV and HCV have significant synergistic effects in the occurrence of PHC.