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目的改进易卒中型肾性高血压大鼠的造模方法。方法以体表定位的方法寻找双肾动脉,复制易卒中型肾性高血压大鼠模型(RHRSP),待大鼠血压升高到一定程度把它们放置于人工模拟气候箱中,给予骤然降温的刺激,观察脑卒中大鼠发病情况。使用SPSS 11.0统计软件,t检验计算各组大鼠血压变化差异。结果易卒中型肾性高血压大鼠模型造模成功。改进后的造模方法使大鼠血压升高快,卒中率达65%。模型组大鼠血压值稳定在205~220mm Hg;模型组与生理组、假手术组的血压值有统计学意义(P<0.05)。气温骤降的变化影响RHRSP脑梗死及脑出血发生的几率。结论采用体表定位的方法,可以减少大鼠的并发症及死亡率并且提高大鼠的脑卒中发生率。气温突变的刺激是脑血管疾病发病的一个重要诱因。
Objective To improve the modeling method of stroke-prone renal hypertensive rats. Methods To search for the renal arteries by means of body surface localization and to copy the rat model of stroke-prone renal hypertension (RHRSP). When rats’ blood pressure increased to a certain extent, they were placed in artificial simulated climate chamber, Stimulation, observe the incidence of stroke in rats. Using SPSS 11.0 statistical software, t test was used to calculate the difference of blood pressure in each group. Results Stroke-induced renal hypertensive rat model was successfully established. Improved modeling methods to rat blood pressure, stroke rate of 65%. The blood pressure of model rats stabilized at 205 ~ 220 mm Hg. The blood pressure of the model group was significantly higher than that of the sham-operation group (P <0.05). Changes in temperature drop affect the incidence of cerebral infarction and cerebral hemorrhage in RHRSP. Conclusion The method of body surface localization can reduce the complication and mortality of rats and increase the incidence of stroke in rats. Stimulation of sudden changes in temperature is an important cause of cerebrovascular disease.