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目的研究小剂量茶碱短期治疗稳定期慢性阻塞性肺疾病(COPD)患者的抗炎疗效。方法 72例稳定期COPD患者,随机分为观察组和对照组,每组36例,两组患者均接受常规治疗,观察组在此基础上再使用小剂量茶碱短期治疗,监测患者血中C反应蛋白、生活质量评分、肺功能、6 min患者的步行距离等指标。结果两组患者血中C反应蛋白、生活质量评分、肺功能、6 min患者的步行距离比较,观察组改善情况明显优于对照组,差异有统计学意义(P<0.05)。结论小剂量茶碱短期治疗稳定期COPD患者的抗炎治疗,有良好的效果。
Objective To study the anti-inflammatory efficacy of short-term theophylline in patients with stable chronic obstructive pulmonary disease (COPD). Methods 72 patients with stable COPD were randomly divided into observation group and control group, 36 cases in each group. Both groups received routine treatment. On the basis of this, the observation group received short-term treatment with low-dose theophylline to monitor the blood C Reactive protein, quality of life score, lung function, walking distance of 6 min and other indicators. Results Compared with the control group, C group reactive protein, quality of life score, lung function and walking distance of patients in 6 min were significantly improved in the two groups (P <0.05). Conclusion Short-term treatment of low-dose theophylline in patients with stable COPD anti-inflammatory treatment, with good results.