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[目的]研究通过建立奥沙利铂致大鼠慢性神经病理痛模型,选择补阳还五汤为代表方揭示其对奥沙利铂致神经病理痛的干预作用。[方法]选取健康清洁级雄性成年大鼠60只,随机分为4组。空白对照组、奥沙利铂组、补阳还五汤对照组和补阳还五汤治疗组。检测4组大鼠热痛阈值并监测大鼠体质量变化。[结果]第2周补阳还五汤治疗组热痛阈值与模型组相比差异有统计学意义。补阳还五汤可拮抗奥沙利铂化疗大鼠引起的热痛阈值和体质量的变化。[结论]补阳还五汤治疗奥沙利铂所致神经病理痛符合中医学的基本理论,该方具有广阔的应用前景。
[Objective] To investigate the intervention effect of Buyang Huanwu Decoction on the neuropathic pain induced by oxaliplatin by establishing oxaliplatin-induced chronic neuropathic pain model in rats. [Method] Sixty healthy male adult rats were randomly divided into 4 groups. Blank control group, oxaliplatin group, Buyang Huanwu Decoction control group and Buyang Huanwu Decoction group. The heat pain threshold of four groups was detected and the body weight of the rats was monitored. [Results] After 2 weeks of treatment, the pain threshold of Buyang Huanwu Decoction group was significantly different from that of model group. Buyanghuanwu can antagonize oxaliplatin chemotherapy induced thermal pain threshold and body weight changes. [Conclusion] Buyang Huanwu Decoction in the treatment of neuropathic pain induced by oxaliplatin conforms to the basic theory of traditional Chinese medicine. This prescription has broad application prospects.