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目的探讨乳腺脂肪肉瘤的临床病理特点及鉴别诊断。方法分析2010年3月收治的1例乳腺多形性脂肪肉瘤的临床表现、组织病理学特征及免疫表型特点,并复习相关文献。结果肿瘤由高级别多形性肉瘤和数量不等的多形性脂肪母细胞组成。免疫组织化学:肿瘤细胞呈S-100蛋白阳性表达、CD34灶性阳性表达,细胞角蛋白、上皮膜抗原、巨噬细胞表面抗原、结蛋白、平滑肌肌动蛋白、肌调节蛋白、肌浆蛋白、CD31均呈阴性表达。结论乳腺脂肪肉瘤是一种少见的原发于乳腺的间叶源性肿瘤,诊断上应首先排除乳腺化生性癌和恶性叶状肿瘤伴脂肪肉瘤分化,应依据形态学特点和免疫组织化学结果进行鉴别。
Objective To investigate the clinicopathological features and differential diagnosis of breast liposarcoma. Methods The clinical manifestations, histopathological features and immunophenotypic features of 1 case of pleomorphic liposarcoma treated in March 2010 were analyzed. The related literatures were reviewed. Results The tumors consisted of high-grade pleomorphic sarcoma and varying numbers of polymorphous lipoblasts. Immunohistochemistry: The tumor cells showed S-100 protein expression, CD34 foci positive expression, cytokeratin, epithelial membrane antigen, macrophage surface antigen, desmin, smooth muscle actin, muscle regulatory protein, sarcoplasmic protein, CD31 were negative expression. Conclusions Breast liposarcoma is a rare primary mesenchymal tumor of the breast. The diagnosis of breast cancer and malignant leaf tumor with liposarcoma should be firstly ruled out. The morphological features and immunohistochemistry results should be used Identification.