氯胺酮自1965被 Domino,Chodoff 和 Corssen 最早报道之后,已广泛应用于麻醉实践。1971年 Galloon 报告用于吸刮终止妊娠时的诱导药物,注意到术中失血少以及术终子宫收缩良好。1973年他在子宫切开术中的子宫肌肉上测量了氯胺酮的效用,发现它具有增加子宫肌张力和收缩强度的双重作用,但1973年 Peltz 和 Sinclair 在剖腹产的妊娠子宫上 Ketamine has been widely used in anesthesia since it was first reported by Domino, Chodoff and Corssen in 1965. In 1971, Galloon reported that it was used to suck induced drugs during termination of pregnancy, noted that there was less intraoperative blood loss and that the uterus contracted well after surgery. In 1973, he measured ketamine’s efficacy on uterine muscle in hysterectomy and found it had dual effects of increasing uterine muscle tone and contractile strength. However, in 1973, Peltz and Sinclair had a caesarean section on the pregnant uterus