论文部分内容阅读
目的:探讨原发性骨神经鞘瘤(Primary schwannoma of the bone,PSB)的临床病理特点,以提高诊断治疗水平。方法:对34例PSB手术切除标本作组织病理学检查,并结合免疫组化、影像学对其进行分析讨论。结果:骨神经鞘瘤病程长,除少数病人无症状体检发现外,大多数表现为受累骨的膨胀,而导致局部肿胀、疼痛。影像学常表现为周边硬化的囊性病变,部分可见骨质破坏。免疫标记S100,GFAP阳性,增殖指数KI-67低。结论:PSB是一种骨内少见的良性肿瘤,生长缓慢,不管良性恶性都可破坏骨质,为避免误诊和过度治疗术中冰冻很重要,必要时可借助免疫组化进行鉴别诊断。
Objective: To investigate the clinicopathological features of primary schwannoma of the bone (PSB) in order to improve the diagnosis and treatment. Methods: 34 cases of PSB resected specimens for histopathological examination, combined with immunohistochemistry, imaging analysis of their discussion. Results: Schwannoma long course, with the exception of a few patients found asymptomatic physical examination, the majority of the performance of the affected bone expansion, leading to local swelling and pain. Imaging often showed cystic lesions of peripheral sclerosis, part of the visible bone destruction. Immunofluorescence S100, GFAP positive, proliferation index KI-67 low. CONCLUSIONS: PSB is a rare benign tumor in bone. It grows slowly and can destroy bone regardless of benign and malignant. It is very important to avoid misdiagnosis and over-treatment of intraoperative freezing. If necessary, PSB can be differentiated by immunohistochemistry.