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目的 :检测胃腺癌组织中胀亡与血管生成素 - 2 (angiopotietin - 2 ,Ang - 2 )的表达。方法 :采用免疫组化SP法检测 6 1例胃腺癌组织及 30例正常胃粘膜组织中Ang - 2的表达 ,并利用透射电镜技术观察其中细胞胀亡情况。结果 :①胃腺癌组织中Ang - 2阳性表达率为 78.6 9% (4 8/ 6 1 ) ,在正常胃粘膜中未见表达 ,差异有统计学意义 ;②胃腺癌组织中发现有不同时期的胀亡细胞 ,胀亡指数 (OI)在Ang - 2阳性和阴性组中分别为 0 .73± 0 .93,2 .98±0 .5 1 ,差异有统计学意义 (P <0 .0 5 ) ;③与无淋巴结转移组比较 ,有淋巴结转移组Ang - 2阳性率较高 ,而OI较低 ,差异均有统计学意义 (P <0 .0 5 ) ;④OI、Ang- 2与胃癌的大体分型、分化程度、组织学类型、肿瘤大小、肿瘤部位及患者性别、年龄无关。结论 :胃腺癌中Ang - 2在促进肿瘤血管形成时 ,促进肿瘤的侵袭转移 ,抑制胀亡的发生
Objective: To detect the expression of angiopoietin - 2 (Ang - 2) in human gastric adenocarcinoma. Methods: Immunohistochemical SP method was used to detect the expression of Ang - 2 in 61 cases of gastric adenocarcinoma and 30 cases of normal gastric mucosa. The cell viability was observed by transmission electron microscopy. Results: ① The positive expression rate of Ang - 2 in gastric adenocarcinoma was 78.6 9% (48/61), which was not found in normal gastric mucosa, the difference was statistically significant; ②The expression of Ang - The number of inflated cells and inflation index (OI) were 0.73 ± 0.93 and 2.98 ± 0.51 respectively in Ang-2 positive and negative groups, the difference was statistically significant (P <0.05 ); ③ Compared with non-lymph node metastasis group, the positive rate of Ang-2 in lymph node metastasis group was higher, while the OI was lower, the difference was statistically significant (P <0.05); ④OI, Ang-2 and gastric cancer General classification, differentiation, histological type, tumor size, tumor location and patient gender, age has nothing to do. Conclusion: Ang - 2 in gastric adenocarcinoma can promote the invasion and metastasis of tumor and restrain the occurrence of bulge when promoting angiogenesis