慢钙通道阻滞剂在治疗各种形式的心绞痛已经显示了效果。虽然所有这类药物均能阻滞钙离子进入收缩细胞,但它们的化学结构和在终末器官的效应有明显不同。为了适应对特殊病人治疗的需要,了解药物特性之间的区别是有必要的。本研究比较了Nicardipine和维拉帕米对慢性阻塞性冠状动脉病和稳定型心绞痛病人运动耐受性的作用。方法:参与研究的22例(男19,女3)病人,年龄43～69岁(平均60岁),具有慢性稳定型心绞痛病史至少三个月。具有静息或不稳定型心绞痛病史者,三个月前急性心肌梗塞的人,生育年龄的妇女以及有明显的心衰,高血压,糖尿病,瓣膜性疾病或心律紊乱的均被排除。服精神病药,利尿药,洋地黄或其他心血管药物的病人也不参加此研究。在12个标准导 Slow calcium channel blockers have shown efficacy in the treatment of various forms of angina. Although all of these drugs block calcium ions from entering the contractile cells, their chemical structure and the effect at the terminal organ are significantly different. In order to adapt to the needs of special patient treatment, it is necessary to understand the difference between the characteristics of the medicines. This study compared the effects of Nicardipine and verapamil on exercise tolerance in patients with chronic obstructive coronary artery disease and stable angina. METHODS: Twenty-two (19 male and 3 female) patients participated in the study, aged from 43 to 69 years (mean, 60 years) with a history of chronic stable angina for at least three months. Patients with a history of either resting or unstable angina were excluded from acute myocardial infarction three months ago, women of childbearing age, and those with significant heart failure, high blood pressure, diabetes mellitus, valvular disease, or cardiac arrhythmias. Patients with psychosis, diuretics, digitalis, or other cardiovascular drugs also did not participate in the study. Guide at 12 standards