本实验观察了家兔甘油性急性肾功能衰竭时异博定对肾脏功能和形状的保护作用。结果表明,异博定能增加肌酐清除率,降低血尿素氮和滤过钠排泄分数,可以保护肾小球、肾小管的细胞结构,有防治急性肾功能衰竭的作用。伤前和伤后立即给药效果好,其机制与异搏定增加肾小球滤过率、保护小管细胞的功能等因素有关。 This experiment observed the protective effect of ibuprofen on renal function and shape in rabbits with glycerol-induced acute renal failure. The results showed that isoprene increased the creatinine clearance rate, reduced blood urea nitrogen and filtered sodium excretion fractions, and could protect the glomerular and tubular cell structures and prevent and treat acute renal failure. The effect of administration before injury and immediately after injury is good, and its mechanism is related to factors such as increasing verapamil filtration rate and protecting the function of the tubule cells.