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目的:研究脑“免疫特免性”与癫痫发病的关系。方法:用免疫细胞化学法观察IgG免疫反应阳性(IgG-IR)细胞在两种不同处理程序的正常成年、癫痫及尼莫地平作用下癫痫大鼠脑组织内分布情况。结果:灌注大鼠,除癫痫组个别脑片散在弱IgG-IR细胞外,其余均阴性;未灌注大鼠,各组脑片均散布IgG-IR细胞;癫痫大鼠脑组织内IgG-IR细胞分布较正常组增多(P<0.01);尼莫地平作用下癫痫大鼠脑组织内IgG-IR细胞分布与正常组比较无显著差异。结论:脑“免疫特免性”在癫痫发病中具有一定意义。
Objective: To study the relationship between brain “immunodeficiency” and epilepsy. Methods: Immunocytochemistry was used to observe the distribution of IgG immunoreactive (IgG-IR) cells in the brain tissue of epileptic rats under normal adult conditions, epilepsy and nimodipine treated by two different treatments. Results: In perfusion rats, except for epilepsy group, individual brain slices were scattered in weak IgG-IR cells, while the others were negative. IgG-IR cells were distributed in each group of brain slices; IgG-IR cells in brain tissue of epileptic rats (P <0.01). The distribution of IgG-IR cells in the brain tissue of epileptic rats under the action of nimodipine had no significant difference compared with the normal group. Conclusion: The brain “immunodeficiency” has some significance in the pathogenesis of epilepsy.