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目的:比较25-羟维生素D3与碱性磷酸酶在婴幼儿维生素D缺乏性佝偻病诊治中的敏感性。方法:对海南省人民医院2006年1月～2008年12月收治的98例年龄为2月～3岁体检或就诊的婴幼儿,检查血清25-羟维生素D3及碱性磷酸酶水平。结果:治疗前25-羟维生素D3浓度明显低于正常对照组(P<0.01),治疗后25-羟维生素D3浓度明显升高,差异有统计学意义(P<0.01)。但治疗前佝偻病组与对照组比较,碱性磷酸酶浓度无统计学差异(P>0.05);治疗后碱性磷酸酶亦无明显变化。结论:25-羟维生素D3在佝偻病初期明显降低,比碱性磷酸酶更敏感,是反映佝偻病活动状态的灵敏指标。
Objective: To compare the sensitivity of 25-hydroxyvitamin D3 and alkaline phosphatase in the diagnosis and treatment of vitamin D deficiency rickets in infants. Methods: A total of 98 infants and young children aged 2 months to 3 years from January 2006 to December 2008 in Hainan Provincial People ’s Hospital were examined for serum 25 - hydroxyvitamin D3 and alkaline phosphatase. Results: Before treatment, the concentration of 25-hydroxyvitamin D3 was significantly lower than that of the normal control group (P <0.01). After treatment, the 25-hydroxyvitamin D3 concentration was significantly increased (P <0.01). However, there was no significant difference in alkaline phosphatase concentration between the rickets control group and the control group before treatment (P> 0.05). There was no significant change in the alkaline phosphatase after treatment. CONCLUSION: 25-hydroxyvitamin D3 is significantly lower than that of alkaline phosphatase in the early stage of rickets, which is a sensitive index reflecting the active state of rickets.