早在1920年 Sprunt 及 Evans 即指出在某种疾病的末梢血液中出现一种病理淋巴细胞,并将该病命名为传染性单核细胞增多症。1923年 Downey 等将此症出现的病理淋巴细胞命名为 Downey 氏细胞,后又改称为异形淋巴细胞、异常淋巴细胞或不典型淋巴细胞(atypical lymphocyte)等。并对此种细胞形态进行了细致观察和描写,同时分为 As early as 1920, Sprunt and Evans pointed out that there is a pathological lymphocyte in the peripheral blood of a certain disease, and named the disease as infectious mononucleosis. In 1923, Downey et al. Named the pathological lymphocytes that appear in this disease as Downey’s cells, and later renamed as abnormal lymphocytes, abnormal lymphocytes or atypical lymphocytes. And the cell morphology was carefully observed and described at the same time divided into