野木瓜注射液可阻滞神经传导和解髓鞘,在临床上有显著的镇痛作用,通过有效成分的分离、提取和初步药理研究,发现其中皂甙有神经传导阻滞作用。神经干外敷0.3％皂甙后,60min起效,使大鼠隐神经复合动作电位A成分下降为给药前的0.22±0.28(n=5),80min时为0.03±0.05,P<0.001。 Wild papaya injection can block nerve conduction and myelination, in the clinical significant analgesic effect, through the separation of active ingredients, extraction and preliminary pharmacological studies, found that saponins have nerve conduction block. After the external application of 0.3% saponin on the nerve trunk, the onset of compound action potential A in the saphenous nerve was decreased to 0.22±0.28 (n=5) before administration and to 0.03±0.05 at 80 minutes, P<0.001.