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毒性中药马钱子的使用历史悠久,临床主要用于治疗跌打损伤、痈疽、神经系统及类风湿性疾病等多种难治性杂症,生品毒性剧烈,治疗剂量与中毒剂量极为接近。研究马钱子炮制工艺与方法,对指导临床合理使用毒性中药意义重大。笔者总结马钱子炮制方法的相关研究文献,总结既往炮制主要目的是降低毒性、便于粉碎、去除绒毛,近年对其传统炮制方法进行改良,发展出更安全有效、简便操作的工艺,并提出研究改良后炮制工艺对毒性中药发挥减毒增效的分子作用机制,为进一步研发马钱子制剂提供理论与临床实践依据。
The toxic traditional Chinese medicine Strychnos has a long history of being used clinically to treat various refractory and complicated diseases such as traumatic injury, ulcer, nervous system and rheumatoid disease, and the toxicity of the product is extremely high. The treatment dose and the poisoning dose are extremely close. Research Strychnos cooked technology and methods, to guide clinical rational use of toxic traditional Chinese medicine is of great significance. The author summarizes the relevant research literature on the processing methods of Strychnos, summarizes the main purpose of the past processing is to reduce toxicity, easy to smash, remove fluff, in recent years to improve its traditional processing methods, the development of safer, more effective and simple operation of the process and put forward research The modified process of the toxic traditional Chinese medicine to exert the molecular mechanism of attenuating synergies, to provide further theoretical and clinical practice basis for the development of Strychnos preparation.