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目的观察复方苦参酊剂对大鼠皮肤的急性毒性反应。方法取60只大鼠,按体重随机分为6组,将受试药物涂于各组动物完整皮肤和破损创面皮肤,观察各组大鼠急性毒性反应。结果与对照组相比,用药后各组大鼠的正常皮肤和破损皮肤均未产生急性毒性反应。结论复方苦参酊剂对大鼠无急性毒性反应,是一种安全性较好的外用制剂。
Objective To observe acute toxicity of Compound Kushen tincture on rat skin. Methods Sixty rats were randomly divided into six groups according to body weight. The test drug was applied to the intact and damaged skin of the animals in each group. The acute toxicity of each group was observed. Results Compared with the control group, no acute toxicity was found on normal skin and damaged skin of rats in each group. Conclusion Compound Sophora tincture has no acute toxicity to rats and is a safe and safe topical preparation.