【摘 要】
：
氧化应激是机体内一种有害的氧化还原失衡状态,是导致组织损伤和疾病发生的重要因素之一.当前畜牧业生产中出现的畜禽繁殖障碍、抗病力下降、生产性能与畜产品品质降低等都与氧化应激有关.核因子E2相关因子2(nuclear factor erythroid 2 related factor,Nrf2)/Kelch 样 ECH 相关蛋白 1(Kelch-like ECH-associated protein 1,Keap1)-抗氧化应答元件(antioxidant response element,ARE)信号通路是
【机 构】
：
中国农业科学院北京畜牧兽医研究所,北京100193
论文部分内容阅读
氧化应激是机体内一种有害的氧化还原失衡状态,是导致组织损伤和疾病发生的重要因素之一.当前畜牧业生产中出现的畜禽繁殖障碍、抗病力下降、生产性能与畜产品品质降低等都与氧化应激有关.核因子E2相关因子2(nuclear factor erythroid 2 related factor,Nrf2)/Kelch 样 ECH 相关蛋白 1(Kelch-like ECH-associated protein 1,Keap1)-抗氧化应答元件(antioxidant response element,ARE)信号通路是机体对抗氧化应激的最重要防御机制之一,通过调控下游多个细胞保护基因的转录,维持胞内氧化还原平衡及代谢和蛋白质稳态,发挥抗炎、抗癌和抗衰老等生物学功能.Nrf2是一种对氧化应激高度敏感的转录因子,在正常生理状态下,与其负调控蛋白Keap1结合,通过泛素-蛋白酶体系统被泛素化和降解.氧化应激导致Nrf2与Keap1解离,Nrf2转位到细胞核内,与小Maf(sMaf)蛋白形成异二聚体并识别ARE序列,启动下游目标基因的转录.由于Nrf2处于复杂调控网络的中心,其活性受到多个水平的严格调控,包括转录及转录后调控、蛋白质稳定性调控、亚细胞定位调控和翻译后修饰调控等.作者介绍了 Nrf2/Keap1-ARE信号通路的分子结构基础、生物学功能、Nrf2活性调控等的研究进展,以期深入了解该通路的调控机制,为提高畜禽健康和提供疾病治疗策略提供理论依据.
其他文献
Background:The Norwegian forest resource map(SR16)maps forest attributes by combining national forest inventory(NFI),airborne laser scanning(ALS)and other remotely sensed data.While the ALS data were acquired over a time interval of 10 years using various
Background:Natural forests in the Hengduan Mountains Region(HDMR)have pivotal ecological functions and provide diverse ecosystem services.Capturing long-term forest disturbance and drivers at a regional scale is crucial for sustainable forest management a
Background:Insect pests are a significant threat to natural resources and social development.Modeling species assemblages of insect pests can predict spatiotemporal pest dynamics.However,research gaps remain regarding the mechanism for determining species
Background:Tree species with narrow ranges are a conservation concern because heightened extinction risk accompanies their small populations.Assessing risks for these species is challenging,however,especially in tropical flora where their sparse populatio
Background:Nitrogen(N)saturation theory proposes that an ecosystem might switch from N limitation to carbon(C),phosphorus(P),or other nutrient limitations if it receives continuous N input.Yet,after N limitation is removed,which nutrient is the most limit
Background:Individual tree extraction from terrestrial laser scanning(TLS)data is a prerequisite for tree-scale estimations of forest biophysical properties.This task currently is undertaken through laborious and time-consuming manual assistance and quali
Background:Nutrient resorption is critical for plants toward balancing their nutritional requirements and adapting to environmental variabilities,which further impacts litter quality and nutrient cycling.However,the interannual variability of nutrient res
Background:Black alder(Alnus glutinosa)forests are in severe decline across their area of distribution due to a disease caused by the soil-borne pathogenic Phytophthora alni species complex(class Oomycetes),“alder Phytopththora”.Mapping of the different t
Background:Forests are an important sink for atmospheric carbon and could release that carbon upon deforestation and degradation.Knowing stand biomass dynamic of evergreen forests has become necessary to improve current biomass production models.The diffe
Background:Water migration and use are important processes in trees.However,it is possible to overestimate transpiration by equating the water absorbed through the plant roots to that diffused back to the atmosphere through stomatal transpiration.Therefor