目的 :在正常猴角膜上做异种人角膜移植成功后 ,尝试在病变猴角膜上做异种人角膜移植。方法 :用 4只猕猴做受体 ,人角膜做供体 ,对猴角膜冷冻后行 5 .5对 5 .0 mm的穿透性角膜移植。术后用 Holland分级标准 ( rejection value,RV)对移植排斥反应强度做临床量化评估。结果 :术后 4～ 7周 RV值明显升高。在局部使用激素的条件下 ,在 2年的观察期内 ,3例植片透明存活 ,1例因排斥反应植片浑浊。结论 :人对猴异种穿透性角膜移植也可以在病变猴角膜上获得成功 OBJECTIVE: After successful heterotopic corneal transplantation on normal cornea, try to make xeno-corneal transplantation on diseased monkey cornea. Methods: Four cynomolgus monkeys were used as recipients. Human corneas were used as donors, and the cornea of ​​the monkey was frozen and then transplanted with a penetrating keratoplasty of 5.5 mm to 5.0 mm. Postoperatively, the Holland rejection scale (RV) was used to evaluate the quantitative evaluation of graft rejection. Results: After 4 ~ 7 weeks RV value was significantly higher. In the topical use of hormones, three of the grafts survived in the 2-year observation period, and one of the implants became opaque due to rejection. CONCLUSIONS: Human-to-monkey hemi-penetrating keratoplasty can also be successful on diseased monkey corneas