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目的分析异丙酚与氯胺酮复合用于小儿麻醉的临床麻醉效果。方法 113例行手术患儿均采取异丙酚与氯胺酮复合静脉麻醉,分析麻醉效果。结果患儿呼吸频率给药前为(21±4)次/min、给药后1 min为(21±5)次/min、给药后5 min为(24±2)次/min、给药后10 min为(24±4)次/min、给药后15 min为(24±2)次/min、给药后20 min为(21±4)次/min,患儿给药前与给药后各时间点呼吸频率比较,差异均无统计学意义(P>0.05)。患儿心率给药前为(112±8)次/min、给药后1 min为(130±5)次/min、给药后5 min为(129±6)次/min、给药后10 min为(123±3)次/min、给药后15 min为(122±4)次/min、给药后20 min为(117±1)次/min,患儿给药前与给药后各时间点心率比较,差异均无统计学意义(P>0.05)。患儿血氧饱和度给药前为(98.1±0.5)%、给药后1 min为(97.5±1.1)%、给药后5 min为(97.4±1.9)%、给药后10 min为(99.1±0.6)%、给药后15 min为(99.2±0.3)%、给药后20 min为(98.5±0.4)%,患儿给药前与给药后各时间点血氧饱和度比较,差异均无统计学意义(P>0.05)。患儿平均动脉压给药前为(85±7)mm Hg(1 mm Hg=0.133 k Pa)、给药后1 min为(84±7)mm Hg、给药后5 min为(90±7)mm Hg、给药后10 min为(86±8)mm Hg、给药后15 min为(84±9)mm Hg、给药后20 min为(84±9)mm Hg,患儿给药前与给药后各时间点平均动脉压比较,差异均无统计学意义(P>0.05)。结论小儿手术麻醉是手术环节中的重点,选择适宜的麻醉药物十分重要,单独使用氯胺酮可能引起生命体征不稳定,并且会出现频繁的麻醉不良反应;异丙酚复合氯胺酮后可稳定患儿的生命体征,是有效的手术麻醉方法。
Objective To analyze the clinical anesthesia effect of propofol combined with ketamine in pediatric anesthesia. Methods A total of 113 children undergoing surgery underwent propofol and ketamine intravenous anesthesia. The anesthetic effect was analyzed. Results The respiratory rate was (21 ± 4) / min before administration, (21 ± 5) min / min at 1 min after administration, and (24 ± 2) min / min at 5 min after administration (24 ± 4) times / min at 10 min after injection, (24 ± 2) min / min at 15 min after administration and (21 ± 4) min / min at 20 min after administration, Respiratory frequency at various time points after drug comparison, the difference was not statistically significant (P> 0.05). The heart rate was (112 ± 8) beats / min before the administration in children, (130 ± 5) beats / min at 1 min after administration and (129 ± 6) beats / min at 5 min after administration, (123 ± 3) beats / min, (122 ± 4) beats / min at 15 min after administration, and (117 ± 1) beats / min at 20 min after drug administration Heart rate at each time point, the difference was not statistically significant (P> 0.05). The blood oxygen saturation of children was (98.1 ± 0.5)% before administration, (97.5 ± 1.1)% 1 min after administration and (97.4 ± 1.9)% 5 min after administration, and (10 99.1 ± 0.6%), (99.2 ± 0.3)% at 15 min after administration and (98.5 ± 0.4)% at 20 min after administration. The blood oxygen saturation of the patients before and after administration was compared, There was no significant difference (P> 0.05). The mean arterial pressure in children before treatment was (85 ± 7) mm Hg (1 mm Hg = 0.133 kPa), one minute after administration was (84 ± 7) mm Hg, and the mean arterial pressure was (90 ± 7) minutes ) mm Hg, (86 ± 8) mm Hg at 10 min after administration, (84 ± 9) mm Hg at 15 min after administration and (84 ± 9) mm Hg at 20 min after administration Before and after administration of mean arterial pressure at each time point, the difference was not statistically significant (P> 0.05). Conclusions Pediatric surgical anesthesia is the key point of the operative procedure. It is very important to choose suitable anesthetic drugs. Ketamine alone may cause instability of vital signs and frequent adverse reactions to anesthesia. Propofol combined with ketamine can stabilize the life of children Signs, is an effective method of surgical anesthesia.