可逆性蛋白磷酸化由蛋白激酶和蛋白磷酸化酶共同参与调节，它是各种细胞活动过程中信号传递的重要机制之一；胞核因子－ｋＢ以非活性状态存在于胞浆中，它与抑制性蛋白结合成复合物；蛋白激酶对抑制性蛋白的磷酸化是胞核因子－ｋＢ活化的重要方式，许多因素通过影响蛋白磷酸化来调节胞核因子－ｋＢ的活化、核转位及其与ＤＮＡ的结合，从而影响靶基因的转录调节。 Reversible protein phosphorylation by the protein kinase and protein phosphorylation of enzymes involved in the regulation, it is a variety of cell activities during signal transmission an important mechanism; nuclear factor-kB in the inactive state exists in the cytoplasm, and Inhibition of protein binding to the complex; protein kinase phosphorylation of inhibitory protein is an important way of activation of nuclear factor-kB, many factors by regulating protein phosphorylation to regulate the activation of nuclear factor-kB, nuclear translocation and its And DNA binding, thus affecting the target gene transcriptional regulation.