药理学治疗量的三环抗忧郁剂(TCA)一般在消化遭充分吸收,与蛋白质结合,迅速分布到全身,达到高浓度,在肝、肺、肾和心脏等处更多.TCA及其代谢物在组织中的浓度比血液中高.这些药物可很快转变为有作用的代谢物,这些代谢物也具有毒性.因此仅测定血中药物浓度,不一定能反映组织和血液中各种有作用物质的真正浓度. Pharmacologically treated tricyclic antidepressants (TCAs) are generally well absorbed in digestion, bound to proteins, rapidly distributed throughout the body, reaching high concentrations and more at the liver, lung, kidney and heart, etc. TCA and its metabolism The concentration of the substance in the tissue is higher than in the blood.These drugs can quickly turn into useful metabolites, which are also toxic, so measuring only the concentration of the drug in the blood does not necessarily reflect the various actions in the tissues and blood The true concentration of matter.