作者报告了三例进行性周围神经病合并孤立性浆细胞瘤。结合文献复习,建议对中年男性有不明原因的进行性周围神经病和脑脊液蛋白升高者应行全身骨骼检查。确诊后给予放射治序可以获得满意疗效。例一、男性39岁,背部和小腿病三周,每走30米时痛加重,基底宽步态,踝部震动觉减退和跟腱反射消失,脑脊液蛋白0.8克/升,左骼骨x线照片呈现泡沫样征象。两个月后病人住院。双腿无力已发 The authors report three cases of progressive peripheral neuropathy complicated with solitary plasmacytoma. Combined with literature review, it is recommended that middle-aged men with unexplained progressive peripheral neuropathy and cerebrospinal fluid protein should be performed in full body bone examination. After the diagnosis of radiation therapy can be obtained satisfactory results. Example 1 Male 39 years old, back and leg disease three weeks, each walking 30 meters increased pain, basal wide gait, ankle vibration loss and Achilles tendon reflex disappeared, CSF protein 0.8 g / l, left ilium The photo shows a foamy sign. Two months later the patient was hospitalized. Legs weakness has been sent