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目的:探讨HER-2/neu和RECK蛋白在乳腺癌组织中的表达及其临床意义。方法:采用SP法,对76例乳腺癌组织标本及30例正常乳腺组织标本进行免疫组化检测,观察乳腺癌组织及正常乳腺组织中HER-2/neu和RECK蛋白表达情况,并比较不同TNM分期、病理分化程度乳腺癌组织HER-2/neu和RECK蛋白表达强度及阳性率差异,分析其两者之间的关系。结果:乳腺癌组织HER-2/neu表达强度及阳性率高于正常乳腺组织,RECK表达强度及阳性率低于正常乳腺组织,乳腺癌组织中HER-2/neu和RECK表达强度及阳性率同TNM分期及肿瘤组织分化具有相关性,乳腺癌组织HER-2/neu和RECK表达呈负相关。结论:乳腺癌组织中HER-2/neu过度表达、RECK表达减弱或缺失的现象,可能是乳腺癌发生、发展的生物学机制之一。
Objective: To investigate the expression and clinical significance of HER-2/neu and RECK proteins in breast cancer. Methods: The SP method was used to detect the expression of HER-2/neu and RECK protein in 76 specimens of breast cancer and 30 specimens of normal breast tissue. The expression of HER-2/neu and RECK protein in breast cancer tissue and normal breast tissue were observed and compared with different TNM. The differences in the intensity and positive rate of HER-2/neu and RECK protein expression in breast cancer tissues during stage and pathological differentiation were analyzed, and the relationship between them was analyzed. Results: The HER-2/neu expression intensity and positive rate in breast cancer tissue were higher than that in normal breast tissue. The RECK expression intensity and positive rate were lower than that in normal breast tissue. The expression and positive rate of HER-2/neu and RECK in breast cancer tissue were same There was a correlation between TNM stage and tumor tissue differentiation. There was a negative correlation between HER-2/neu and RECK expression in breast cancer tissues. CONCLUSION: The over-expression of HER-2/neu in breast cancer tissues and the weakened or missing expression of RECK may be one of the biological mechanisms of the occurrence and development of breast cancer.