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目的:探讨甲酰四氢叶酸钙(CF)解救大剂量甲氨蝶呤(HDMTX)化疗致急性淋巴细胞白血病(ALL)患儿胃肠道黏膜损伤的效果。方法:将25例患儿随机分为观察组13例和对照组12例,两组化疗总量、疗程、准备工作等相同,观察组在12 h静脉滴注完甲氨蝶呤(MTX)后第12小时使用CF解救,对照组在6.5 h静脉滴注完MTX后第29.5小时使用CF解救。观察两组患儿恶心和呕吐程度、口腔黏膜反应程度、反应持续时间。结果:两组患儿化疗后胃肠道反应程度、口腔黏膜反应程度、反应持续时间比较差异均有统计学意义(P<0.01)。结论:24 h静脉滴注MTX后第12小时开始给予CF解救更有利于保护胃肠道和口腔黏膜,促进受损组织细胞修复,提高化疗效果和患儿生存质量,具有较好的临床应用价值。
Objective: To investigate the effect of levofloxacin (CF) on gastrointestinal mucosal injury in children with acute lymphoblastic leukemia (ALL) treated with high dose methotrexate (HDMTX). Methods: Twenty-five children were randomly divided into observation group (n = 13) and control group (n = 12). The total amount, course of treatment and preparation were the same in both groups. After 12 hours of intravenous MTX CF was rescued at 12 hours and control group was rescued at 29.5 hours after intravenous infusion of MTX at 6.5 hours. The degree of nausea and vomiting, the degree of oral mucosal reaction and the duration of reaction in both groups were observed. Results: The degree of gastrointestinal reaction, the degree of oral mucosal reaction and the duration of response after chemotherapy in both groups were statistically significant (P <0.01). CONCLUSION: The rescue of CF started 12 hours after intravenous infusion of MTX 24 h is more beneficial to protect the gastrointestinal tract and oral mucosa, promote the repair of damaged tissue cells, improve the chemotherapy effect and quality of life of children, and has a good clinical value .