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目的探讨肝硬化及食管静脉曲张与血浆降钙素基因相关肽(CGRP)的关系。方法用放免法检测61例肝硬化患者和24例正常人血浆CGRP,并与其相关因素进行分析。结果肝硬化组血浆CGRP水平犤(119.21±35.62)ng/L犦显著高于正常对照组犤(79.47±18.83)ng/L犦(P<0.05),且在肝功能分级中,呈现ChildC级者>ChildB级者>ChildA级者的规律。肝硬化患者血浆CGRP水平与门静脉直径呈明显正相关(r=0.60,P<0.01)。肝硬化并发食管静脉曲张组CGRP浓度为(133.85±36.12)ng/L,未并发食管静脉曲张组为(89.20±31.67)ng/L,前者明显高于后者(P<0.05)。多元Logistic回归分析发现肝硬化患者血浆CGRP升高、门静脉直径增宽及肝功能Child分级升高与肝硬化食管静脉曲张发病独立相关。结论肝硬化患者血浆CGRP水平反映了肝硬化的严重程度,可能与肝硬化食管静脉曲张发病有关。
Objective To investigate the relationship between cirrhosis and esophageal varices and plasma calcitonin gene related peptide (CGRP). Methods The plasma CGRP level in 61 cirrhotic patients and 24 healthy controls were detected by radioimmunoassay and the related factors were analyzed. Results The level of CGRP in cirrhosis group was significantly higher than that in control group (119.21 ± 35.62) ng / L 79 (79.47 ± 18.83) ng / L 犦 (P <0.05) > ChildB class> ChildA class who’s rule. The level of plasma CGRP in cirrhotic patients was positively correlated with portal vein diameter (r = 0.60, P <0.01). The CGRP concentration was (133.85 ± 36.12) ng / L in cirrhotic patients with esophageal varices and (89.20 ± 31.67) ng / L in patients without esophageal varices, the former was significantly higher than the latter (P <0.05). Multivariate logistic regression analysis found that patients with cirrhosis of the plasma CGRP increased portal vein diameter and liver function Child classification and liver cirrhosis independently associated with the incidence of esophageal varices. Conclusion The level of plasma CGRP in patients with cirrhosis reflects the severity of cirrhosis and may be related to the pathogenesis of cirrhosis esophageal varices.