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细胞色素P450(CYP450)是一类存在于肝脏内质网上的蛋白质超家族,参与的生化反应有固醇类生物合成、脂肪酸和类固醇激素等内源性底物的氧化代谢、大部分药物和外源物的生物氧化等。90%以上药物的代谢都要通过肝微粒体细胞色素P450。由遗传或环境因素导致不同个体P450基因突变从
Cytochrome P450 (CYP450) is a type of protein superfamily that exists in the liver endoplasmic reticulum and is involved in the biochemical reactions of sterol biosynthesis, oxidative metabolism of endogenous substrates such as fatty acids and steroid hormones, and most drugs and Biological oxidation of the source material. More than 90% of the drug metabolism through the liver microsomal cytochrome P450. P450 gene mutations from different individuals caused by genetic or environmental factors