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目的探讨泛耐药鲍曼不动杆菌神经系统感染的治疗策略。方法结合临床药师亲身参与的1例泛耐药鲍曼不动杆菌神经系统感染的治疗,介绍多黏菌素B在治疗中的合理应用。结果临床药师推荐通过多黏菌素B局部给药方式,加强局部组织药物浓度,提高泛耐药鲍曼不动杆菌治疗效果。同时,在多黏菌素B的应用剂量、途径、监护等多方面提供了合理建议。患者感染最终得以控制,未出现肾毒性和神经毒性反应。结论多黏菌素B的局部用药为泛耐药鲍曼不动杆菌神经系统感染治疗提供了新思路。
Objective To investigate the treatment strategy of pan-drug resistant Acinetobacter baumannii nervous system infection. Methods One case of Acinetobacter baumannii infection with clinical pharmacists was involved in the treatment of nervous system infection. The rational application of polymyxin B in the treatment was introduced. Results Clinical pharmacists recommended local administration of polymyxin B to enhance the local tissue drug concentration and improve the therapeutic effect of pan-drug-resistant Acinetobacter baumannii. At the same time, the application of polymyxin B dose, ways, guardianship and other aspects provide reasonable advice. Patient infection was eventually controlled without nephrotoxicity and neurotoxicity. Conclusion The topical application of polymyxin B provides a new idea for the treatment of Pancreatic Acinetobacter baumannii nervous system infection.