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猪水泡病于1966年在意大利首次发现(Nardelli等1968),生理化学测定表明病原体是一种肠道病毒。而后的爆发发于1971年香港(MoWa,Dtarbyshire和Hantleyl972)和1972—1975在欧洲和日本(Brooks byl975)。猪水泡病病毒能被柯萨奇B5抗血清所中和这一重要发现(Graues,1973),激起了对猪病毒起源问題的重视。 Brown,Talbot和BarroWs(1973)初步实验表明尽管两病毒之间关系接近,但能被免疫扩散试验所区别。本报告的结果表明两病毒也能用中和试验区別。报道了以病毒核糖核酸的同源试验,支持了血清学责料,也得到的另外一种对两个病毒之间关系的测定方法,这些责料说明可能弄清猪病毒的起源。
Porcine blister disease was first discovered in Italy in 1966 (Nardelli et al., 1968) and the physico-chemical assay indicated that the pathogen was an enterovirus. The subsequent outbreaks occurred in Hong Kong in 1971 (MoWa, Dtarbyshire and Hantleyl 972) and in 1972-1975 in Europe and Japan (Brooks byl975). The swine vesicular disease virus can be neutralized by the Coxsackie B5 antisera (Graues, 1973), raising the awareness of the origin of the swine virus. Preliminary experiments by Brown, Talbot and BarroWs (1973) show that although the relationship between the two viruses is similar, they can be distinguished by immunodiffusion tests. The results of this report show that the two viruses can also use neutralization test difference. A homologous test with viral RNA was reported to support serological testing and to obtain a second measure of the relationship between the two viruses that may shed light on the origin of the swine virus.