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观察亚临床维生素A缺乏(SVAD)儿童淋巴细胞增殖、IL-2、IL-6和B细胞生长因子活性(BCGF)及体外IgG亚类产生能力;并行维生素A酸(RA)体外纠正试验和口服维生索A(VitA)1月后随访。结果示IL-2、IL-6和BCGF活性,T细胞和B细胞增殖反应,以及IgG1,IgG2和IgG4体外产量在SVAD组明显低于维生素A正常组(VAN)。IgG3在SVAD和VAN组间无差别。IL-2、IL-6活性、IgG1、IgG2产量与血清VitA水平量正相关,IgG1、IgG2产量与IL-6活性正相关。体外RA纠正试验或体内补充VitA后,上述免疫学指标均有不同程度恢复。本文提示VAD主要损伤T细胞,尤其是TH2细咆及其细胞因子,间接影响B细胞分化,导致IgG及其亚类合成转换障碍。
To observe the lymphocyte proliferation, IL-2, IL-6 and B cell growth factor activities (BCGF) and IgG subclass production capacity in children with subclinical vitamin A deficiency (SVAD); in vitro correction test with vitamin A acid (RA) Vitas A was followed up in January. The results showed that IL-2, IL-6 and BCGF activities, T cell and B cell proliferative responses, and the in vitro yields of IgG1, IgG2 and IgG4 were significantly lower in the SVAD group than in the normal vitamin A group (VAN). IgG3 did not differ between SVAD and VAN groups. IL-2, IL-6 activity, IgG1, IgG2 production and serum VitA levels were positively correlated, IgG1, IgG2 production and IL-6 activity was positively correlated. In vitro RA correction test or in vivo VitA supplementation, the above immunological indicators have different degrees of recovery. This paper suggests that VAD mainly damages T cells, especially TH2 cells and their cytokines, indirectly affecting B cell differentiation, resulting in the conversion disorder of IgG and its subclasses.